Key result
Spontaneously hypertensive rats exhibited increased parenchymal arteriole myogenic tone and basal Ca(2+) oscillation frequency, but maintained similar neuronal stimulation-evoked dilations compared to normotensive rats.
Why the study?
Does hypertension alter cortical parenchymal arteriole function or astrocyte signaling to blunt neurovascular coupling in spontaneously hypertensive rats?
Population
Cortical brain slices and parenchymal arterioles from normotensive Wistar Kyoto and spontaneously…
Comparison
Various stimuli including thromboxane A2… vs Normotensive Wistar Kyoto (WKY) rats
Design
Preclinical
Authors
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Hypertension may impair neurovascular coupling via arteriole tone and astrocyte changes in rodents; leaves open human translation and therapeutic targets.
Does hypertension alter cortical parenchymal arteriole function or astrocyte signaling to blunt neurovascular coupling in spontaneously hypertensive rats?
Neurovascular coupling is not impaired at the level of parenchymal arterioles in spontaneously hypertensive rats, despite increased myogenic tone and altered calcium dynamics.
Iddings et al. (2015) studied Hypertension. Spontaneous hypertension (SHR) vs. Normotensive Wistar Kyoto (WKY) rats was evaluated on Parenchymal arteriole reactivity and vascular smooth muscle cell Ca(2+) dynamics. Spontaneously hypertensive rats exhibited increased parenchymal arteriole myogenic tone and basal Ca(2+) oscillation frequency, but maintained similar neuronal stimulation-evoked dilations compared to normotensive rats.
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