What question did this study set out to answer?

To evaluate the clinical features, causative agents, and outcomes of idiosyncratic drug-induced acute liver failure.

August 31, 2010Hepatology

Drug-Induced Acute Liver Failure

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Authors

ARAdrian ReubenMedical University of South Carolina DKDavid KochMedical University of South Carolina WLWilliam M. LeeRutgers, The State University of New Jersey

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Implication

Prospective cohort study observes low spontaneous survival but high post-transplant survival in drug-induced liver failure, highlighting the vital role of liver transplantation.

Key Points

To evaluate the clinical features, causative agents, and outcomes of idiosyncratic drug-induced acute liver failure.
Prospective cohort study enrolling 1,198 subjects with acute liver failure across 23 tertiary liver transplant sites in the United States over a 10.5-year period.
Expert panel adjudication to identify drug-induced liver injury (DILI) cases and categorize causality as highly likely, probable, or possible.
DILI accounted for 133 of 1,198 acute liver failure cases (11.1%), occurred predominantly in women (70.7%), and was most frequently caused by antimicrobials (46%).
Transplant-free 3-week survival was 27.1%, while 42.1% received liver transplants, resulting in an overall survival rate of 66.2%.
Transplant-free survival was significantly determined by baseline levels of bilirubin, prothrombin time/international normalized ratio, and Model for End-Stage Liver Disease scores.

Cite This Study

Reuben et al. (2010) studied this question.

synapsesocial.com/papers/6a03323e4f17ebd438652965 https://doi.org/10.1002/hep.23937

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Implication

Prospective cohort study observes low spontaneous survival but high post-transplant survival in drug-induced liver failure, highlighting the vital role of liver transplantation.

Drug-Induced Acute Liver Failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Drug-Induced Acute Liver Failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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