Does Torque teno virus viral load correlate with immune reconstitution markers in youths with vertically acquired HIV?
Torque teno virus viral load correlates with immune reconstitution and activation markers in youths with vertically acquired HIV, suggesting its potential as a biomarker.
IQR: 574-906, a median of 17 years IQR: 14-20.5 since ART initiation, and 65 months IQR: 39-116 under HIV-RNA virological control. TTV VL was higher among YWVH and in males compared with females (p < 0.05). Among YWVH, TTV VL correlated with CD4 and CD8 counts and the CD4/CD8 ratio (p = 0.002; r = - 0.39, p = 0.037; r = 0.277, p = 0.005; r = - 0.37 respectively). TTV VL correlated with activation expression markers (HLA-DR+/CD38+) on CD4 (p = 0.007, r = 0.39) and the soluble proinflammatory cytokine IL-6 (p = 0.006, r = 0.38).
Tarancón‐Díez et al. (Mon,) studied this question.