Why the study?
Does sildenafil improve exercise performance in children and young adults after the Fontan operation?
Population
Children and young adults with single-ventricle physiology after the Fontan operation
Comparison
Sildenafil 20 mg oral three times daily for 6… vs Placebo for 6 weeks
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
6 weeks per treatment phase
Authors
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Supports sildenafil to optimize exercise ventilatory efficiency post-Fontan; extends PDE5 inhibitor evidence in pediatric single-ventricle physiology.
Does sildenafil improve exercise performance in children and young adults after the Fontan operation?
Sildenafil improves ventilatory efficiency during peak and submaximal exercise in children and young adults with single-ventricle physiology post-Fontan.
Goldberg et al. (2011) studied this question.
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