Immunocytochemical analysis demonstrates selective binding of synapsin I to small synaptic vesicles in bovine hypothalamus, explaining neuron-specific protein localization.
Immunocytochemistry revealed that synapsin I is preferentially (and possibly exclusively) associated with small (40- to 60-nanometer) synaptic vesicles and not with large (greater than 60-nanometer) dense-core vesicles in bovine hypothalamus. These observations may explain why synapsin I is found exclusively in neurons, since small synaptic vesicles are specific to neurons whereas large dense-core vesicles in neurons may be considered the equivalent of secretory organelles in endocrine cells.
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Navone et al. (1984) studied this question.
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