Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome

Elisabeth B. Budal; Mariann H. L. Bentsen; Jörg Kessler; Cathrine Ebbing; Paul Christoffer Lindemann; Olav H. Haugen; Stein Magnus Aukland; Geir Egil Eide; Thomas Halvorsen; Karin Collett

doi:10.1080/14767058.2023.2196599

April 9, 2023The Journal of Maternal-Fetal & Neonatal MedicineOpen Access

Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome

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Key Points

To assess whether a fetal inflammatory response or a positive maternal microbiological culture relates to adverse neonatal outcomes in extremely preterm infants with histologic chorioamnionitis.
Conducted a prospective observational cohort study of singleton pregnancies delivering at ≤28 weeks of gestation with confirmed histologic chorioamnionitis.
Identified fetal inflammatory response by the presence of neutrophils in chorionic or umbilical vessels, and analyzed bacterial cultures from maternal cervicovaginal tracts or placenta.
Applied logistic regression to evaluate associations between inflammatory markers and outcomes, including bronchopulmonary dysplasia, MRI brain pathology, and perinatal death.
Microbiological sampling was completed in 63 of 71 cases (89%), with no significant associations observed between a positive culture and adverse neonatal outcomes.
The presence of a fetal inflammatory response was significantly associated with both bronchopulmonary dysplasia and magnetic resonance imaging-detected brain pathology.

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Implication

Prospective cohort study reveals fetal inflammatory response links to brain and lung injury in extremely preterm infants, indicating fetal immune activation drives adverse neonatal prognosis.

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Cite This Study

Budal et al. (2023) studied this question.

synapsesocial.com/papers/6a033b2aa7089d6435654091 https://doi.org/10.1080/14767058.2023.2196599

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Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome

Key Points

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Implication

Discussion

Cite This Study

Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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