Laboratory study reveals TSG-6 upregulation promotes extracellular matrix degradation in HT-2 toxin-exposed chondrocytes, suggesting a pathological mechanism in Kashin-Beck disease.
The upregulation of the TSG-6 gene may play a role in promoting the damage and degradation of the extracellular matrix in KBD chondrocytes under the exposure of HT-2 toxin.
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Ning et al. (2022) studied this question.
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