What question did this study set out to answer?

To examine in vivo bystander cross-regulation between helminth-induced Th2 responses and bacterial-induced Th1 immunity during concurrent infection and vaccination.

October 1, 1999Infection and ImmunityOpen Access

Fasciola hepaticaSuppresses a Protective Th1 Response againstBordetella pertussis

View Full Paper

Ask AI

Bookmark

Authors

MBMiriam T. BradyTrinity College SOSandra M. O’NeillUniversity of Dundee JDJohn P. DaltonOllscoil na Gaillimhe – University of Galway

Discussion

Member takes

Implication

Preclinical mouse study reveals that Fasciola hepatica suppresses Th1 immunity against Bordetella pertussis, indicating helminths can impair bacterial vaccine efficacy.

Key Points

To examine in vivo bystander cross-regulation between helminth-induced Th2 responses and bacterial-induced Th1 immunity during concurrent infection and vaccination.
Assessed cytokine profiles and bacterial clearance in mice coinfected with Fasciola hepatica and Bordetella pertussis or infected sequentially following whole-cell pertussis (Pw) vaccination.
Investigated the mechanistic requirement of Th2 signaling pathways using interleukin-4 (IL-4) knockout mice.
Concurrent F. hepatica infection markedly suppressed B. pertussis-specific Th1 cytokine responses and exacerbated bacterial infection while maintaining parasite-specific Th2 cytokine polarization.
Infection with F. hepatica suppressed established Th1 responses generated by prior B. pertussis infection or parenteral Pw vaccination across both induction and effector phases.
Immunomodulatory suppression of B. pertussis immunity was significantly reduced, though not completely eliminated, in IL-4-deficient mice.

Cite This Study

Brady et al. (1999) studied this question.

synapsesocial.com/papers/6a03411f4f17ebd438652f49 https://doi.org/10.1128/iai.67.10.5372-5378.1999

View Full Paper

Ask AI

Bookmark

Implication

Preclinical mouse study reveals that Fasciola hepatica suppresses Th1 immunity against Bordetella pertussis, indicating helminths can impair bacterial vaccine efficacy.

Fasciola hepaticaSuppresses a Protective Th1 Response againstBordetella pertussis

Discussion

Member takes

Implication

Key Points

Cite This Study

Fasciola hepaticaSuppresses a Protective Th1 Response againstBordetella pertussis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider