Why the study?
Platelet responses are associated with end-organ injury and mortality after complex insults such as cardiac surgery, but how platelets contribute remains unclear.
Does inhibition of platelet activation prevent mast cell-dependent inflammation and tissue injury in a rat cardiac surgery model?
Does inhibition of platelet activation prevent mast cell-dependent inflammation and tissue injury in a rat cardiac surgery model?
Platelets trigger local and systemic inflammatory responses and tissue injury through PAF-mediated activation of perivascular mast cells, suggesting platelet inhibition may mitigate end-organ injury after cardiac surgery.
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Platelet inhibition may blunt post-surgical inflammation in rat models; hypothesis-generating for PAF-targeted therapies in human cardiac surgery.
Karhausen et al. (2020) studied this question.
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