Why the study?
Advances in laboratory instrumentation and high-sensitivity methods allow detection of cardiospecific troponins in non-blood biological fluids, raising questions about their clinical and diagnostic value.
What is the clinical and diagnostic value of measuring cardio-specific troponins in various human biological fluids?
What is the clinical and diagnostic value of measuring cardio-specific troponins in various human biological fluids?
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High-sensitivity assays enable the detection of cardiac troponins in non-traditional biological fluids like urine and oral fluid, potentially expanding non-invasive diagnostic options.
The article is devoted to problems of clinical-diagnostic value of determination of cardio-specific troponins in human biological fluids. Improvement of laboratory instrumentation and emergence of high sensitivity methods of analysis have allowed to identify troponins in urine, dialysate, and oral fluid. In the review we present actual information related to measurement of troponins in blood serum, data on testing of cardio-specific troponins in urine, dialysate, and oral fluid. Special attention is paid to determination of some cardiomarkers in oral fluid with thorough analysis of diagnostic value and effectiveness of the conducted studies.
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Chaulin et al. (2019) studied this question.
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