What question did this study set out to answer?

To examine the physiological mechanisms driving disuse-induced insulin resistance and skeletal muscle atrophy following a short period of bed rest.

June 29, 2016Socio-Environmental Systems ModelingOpen Access

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

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Authors

MDMarlou L. DirksUniversity of Exeter BWBenjamin T. WallPrincess Margaret Hospital for Children BVBas van de ValkMaastricht University

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Implication

Experimental bed-rest study demonstrates that one week of strict disuse induces muscle atrophy and insulin resistance in young males, suggesting mechanisms independent of lipid accumulation.

Key Points

To examine the physiological mechanisms driving disuse-induced insulin resistance and skeletal muscle atrophy following a short period of bed rest.
Ten healthy young males (age 23 ± 1 years, BMI 23.0 ± 0.9 kg/m²) underwent 1 week of strict bed rest.
Assessed lean body mass (DXA), quadriceps cross-sectional area (CT), VO2peak, leg strength (1RM), and whole-body insulin sensitivity via hyperinsulinemic-euglycemic clamp before and after bed rest.
Obtained muscle biopsies to quantify lipid accumulation and saturation, markers of mitochondrial and vascular content, and oxidative stress.
Bed rest induced a 1.4 ± 0.2 kg loss in lean tissue and a 3.2 ± 0.9% decrease in quadriceps cross-sectional area (both P < 0.01).
Whole-body insulin sensitivity decreased by 29 ± 5% (P < 0.01), alongside reductions in VO2peak of 6.4 ± 2.3% (P < 0.05) and one-repetition maximum of 6.9 ± 1.4% (P < 0.01).
Muscle oxidative capacity significantly declined, while muscle lipid content, lipid saturation levels, oxidative stress markers, and capillary density remained unchanged.

Cite This Study

Dirks et al. (2016) studied this question.

synapsesocial.com/papers/6a03482ddaa0ebdf9f9e5841 https://doi.org/10.2337/db15-1661

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Implication

Experimental bed-rest study demonstrates that one week of strict disuse induces muscle atrophy and insulin resistance in young males, suggesting mechanisms independent of lipid accumulation.

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

Discussion

Member takes

Implication

Key Points

Cite This Study

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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