Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 14, 1997Proceedings of the National Academy of SciencesOpen Access

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

View Full Paper
Ask AI
Bookmark
Share

Authors

NRNathalie Rouas‐FreissInsermRBRachel Bras‐GonçalvesCentre de Coopération Internationale en Recherche Agronomique pour le DéveloppementCMCatherine MenierCommissariat à l'Énergie Atomique et aux Énergies Alternatives

Discussion

Loading...

Member takes

Implication

Experimental study reveals HLA-G prevents uterine natural killer cytolysis of cytotrophoblasts, indicating a direct mechanism for fetal semiallograft survival.

Key Points

  • To determine whether HLA-G expression under physiological conditions directly protects fetal cytotrophoblasts from maternal uterine natural killer cell cytolysis.
  • Tested cytolysis across 6 semiallogenic pairs of maternal uterine NK cells and autologous cytotrophoblasts, as well as 20 allogenic maternal NK cell and trophoblast combinations.
  • Inhibited HLA-G activity in cytotrophoblasts and HLA-G1-transfected K562 cell lines using an HLA-G-specific monoclonal antibody to evaluate susceptibility to uterine NK-mediated lysis.
  • Cytotrophoblasts expressing HLA-G were completely protected against uterine NK cell lysis in all 6 semiallogenic and all 20 allogenic donor combinations.
  • Treatment with an HLA-G-specific monoclonal antibody abolished this protection across all cases, and HLA-G1 transfection into K562 cells conferred antibody-reversible protection against uterine NK lysis.

Cite This Study

Rouas‐Freiss et al. (1997) studied this question.

synapsesocial.com/papers/6a0349b0bc3ffe278e65605ehttps://doi.org/10.1073/pnas.94.21.11520
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of killer cell inhibitory receptors on human uterine natural killer cells1997 · 187 citations
  2. 2P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.1993 · 535 citations
  3. 3Evidence for the expression of HLAA-C class I mRNA and protein by human first trimester trophoblast1996 · 252 citations
  4. 4The HLA-A,B "negative" mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon1992 · 289 citations
  5. 5The mother–child union: The case of missing-self and protection of the fetus1997 · 32 citations