Why the study?
Does long-term genetic exposure to lower systolic blood pressure reduce the age-related rise in systolic blood pressure and the risk of coronary heart disease?
Population
≤199,477 participants in 63 studies for blood pressure analysis, and 22,223 coronary heart disease cases and…
Comparison
12 polymorphisms associated with lower systolic… vs Absence of these polymorphisms (genetic control)
Design
Meta-analysis, Naturally random allocation (Mendelian randomization)
Follow-up
Lifetime (long-term exposure)
Authors
Loading...
Genetic SBP lowering may confer amplified CHD protection; leaves open clinical translation beyond short-term trials.
Does long-term genetic exposure to lower systolic blood pressure reduce the age-related rise in systolic blood pressure and the risk of coronary heart disease?
Long-term genetic exposure to lower systolic blood pressure is associated with a slower age-related rise in blood pressure and a substantially greater reduction in coronary heart disease risk than short-term pharmacological treatment.
Ference et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: