Answers are grounded in this paper and cite their sources.
Objective: To explore the association between genetic status and mood related disorders before and after diagnosis of PD and the association between mood-related medications, phenotype, and genetic status. Methods: Participants were genotyped for mutations in the LRRK2 and GBA genes. State of depression, anxiety and non-motor features were evaluated using validated questionnaires. History of mood disorders prior to diagnosis of PD and use of mood-related medications were assessed. Conclusions: -PD with mood-related disorders experience high rates of anxiety and depression despite treatment, attesting to the need of more precise assessment and treatment of these genetic subgroups.
No takes yet. Share an insight, caveat, or question.
DeBroff et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: