What question did this study set out to answer?

Determine the cellular mechanisms in cortical neurons that govern the perceptual threshold for detecting sensory stimuli.

December 22, 2016ScienceOpen Access

Active cortical dendrites modulate perception

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Authors

NTNaoya TakahashiNihon University TOThomas G. OertnerUniversität Hamburg PHPeter HegemannHumboldt-Universität zu Berlin

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Implication

Animal study reveals that dendritic calcium signaling regulates tactile detection thresholds in mice, indicating that active dendrites determine sensory perception.

Key Points

Determine the cellular mechanisms in cortical neurons that govern the perceptual threshold for detecting sensory stimuli.
Combined in vivo two-photon imaging, electrophysiology, optogenetics, and behavioral tracking in mice.
Measured and suppressed calcium signaling in the apical dendrites of pyramidal neurons within the somatosensory cortex during whisker stimulation.
Calcium signals in the apical dendrites of somatosensory pyramidal neurons directly controlled the perceptual detection threshold for whisker touch.
Strong optogenetic or physiological reduction of dendritic calcium signaling significantly impaired stimulus detection, causing previously perceptible stimuli to go unnoticed.

Cite This Study

Takahashi et al. (2016) studied this question.

synapsesocial.com/papers/6a0358f64f17ebd4386533ba https://doi.org/10.1126/science.aah6066

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Implication

Animal study reveals that dendritic calcium signaling regulates tactile detection thresholds in mice, indicating that active dendrites determine sensory perception.

Active cortical dendrites modulate perception

Discussion

Member takes

Implication

Key Points

Cite This Study

Active cortical dendrites modulate perception

Discussion

Member takes

Implication

Key Points

Cite This Study

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