Why the study?
Does Roux-en-Y gastric bypass improve cardiometabolic risk biomarkers in individuals with obesity?
Does Roux-en-Y gastric bypass improve cardiometabolic risk biomarkers in individuals with obesity?
Roux-en-Y gastric bypass significantly improves cardiometabolic risk biomarkers at 6 months, driven by increases in adiponectin and decreases in resistin.
RYGB may favorably alter adipokine profiles in obesity; leaves open whether this reduces cardiovascular events.
< 0.05. Among 36 mostly female patients aged 30 to 39 years, significant reductions in body weight (-26.8%), fat mass (-50%), waist circumference (-18%) and waist-to-height ratio (-22%) were observed post-surgery. Serum adiponectin levels increased (+107%), while resistin (-12.2%), TNF-α (-35%), and PAI-1 (-11.1%) decreased. Glucose, insulin, CRP, cholesterol, LDL-c, triglycerides, and vitamin D also decreased. Waist circumference variation showed a positive correlation with PAI-1 and TNF-α and a negative correlation with adiponectin. The total fat mass showed a positive correlation with PAI-1. Adiponectin variation correlated negatively with glucose, resistin, and CRP but positively with HDL-c. Resistin showed a positive correlation with insulin and CRP. In conclusion, 6 months post-bariatric surgery, reducing abdominal adiposity had a more significant impact on serum adipokine levels than total fat mass. Adiponectin increase and resistin decrease acted as endocrine mediators driving the remission of cardiometabolic risk biomarkers in individuals with obesity following Roux-en-Y gastric bypass.
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Fiorotti et al. (2024) studied this question.
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