Key result
Bariatric surgery significantly increased adiponectin levels from 17.54 μg/mL at baseline to 68.76 μg/mL at 6 months post-surgery, alleviating systemic inflammation.
Why the study?
Bariatric surgery improves adipose tissue dysfunction in obesity, but the mechanisms underlying this amelioration remain unknown.
Does bariatric surgery improve circulating adipo-cytokines and insulin resistance in individuals with morbid obesity?
Case-Control (n=60)
Does bariatric surgery improve circulating adipo-cytokines and insulin resistance in individuals with morbid obesity?
Bariatric surgery significantly improves systemic inflammation and insulin resistance markers at 6 months post-operation in morbidly obese individuals.
Bariatric surgery may improve inflammatory markers in morbid obesity; leaves open effects on hard outcomes pending RCTs.
BACKGROUND: Bariatric surgery has emerged as a promising treatment for improving adipose tissue dysfunction in obesity, but the mechanisms for such amelioration are still not known. This study comprehensively explores a panel of adipo-cytokines in individuals with obesity undergoing bariatric surgery, in conjunction with markers of insulin resistance, at three time points i.e., pre-op, immediate post-op and 6 months post-surgery. METHODS: It is a case-control prospective study among obese individuals undergoing bariatric surgery (BMI ≥35 kg/m2, n=30) and non-obese subjects (BMI <25 kg/m2, n=30), comparing the levels of serum adiponectin, resistin, C-Reactive Protein (CRP), Interleukin (IL)-6 and 8, Monocyte chemoattractant protein (MCP)-1 and Tumor necrosis factor (TNF)-α between them. The same were followed at immediate and 6-month post-op periods in the former group. The serum markers were correlated with the markers of Insulin resistance like HOMA-IR, HOMA-β and QUICKI. RESULTS: A significant increase in adiponectin was seen after weight loss in obese group (17.54 ± 1.31 μg/mL at baseline vs 68.76 ± 1.84 μg/mL at 6- month post-surgery). CRP being an acute phase protein showed significant higher levels at immediate post-op period but declined even below its baseline at 6 months after surgery (33.34 ± 16.85 μg/mL at baseline vs 59.85 ± 23.12 μg/mL at immediate post-op vs 9.66 ± 1.84 μg/mL at 6 months post-operatively). Few inconsistencies were observed in the trajectories of IL-6 and TNF-α, while other pro-inflammatory markers indicated resolution after surgery. CONCLUSION: Bariatric surgery alleviated the systemic inflammation, correlating with improved insulin resistance in individuals with obesity.
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Sachan et al. (2021) conducted a case-control in Morbid obesity (n=60). Bariatric surgery vs. Non-obese subjects was evaluated on Levels of serum adipo-cytokines and markers of insulin resistance. Bariatric surgery significantly increased adiponectin levels from 17.54 μg/mL at baseline to 68.76 μg/mL at 6 months post-surgery, alleviating systemic inflammation.
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