Key result
Bariatric and metabolic surgery significantly reduced the HOMA-IR index from 3.4 to 1.3 at 3 months, preceding the significant resolution of systemic inflammatory markers at 6 months.
Why the study?
The sequence and timing of metabolic improvement versus inflammation resolution after bariatric and metabolic surgery, particularly regarding Th17 and Th1 cell responses, has been rarely explored.
Population
Subjects with obesity undergoing bariatric and metabolic surgery
Comparison
Pre-surgery vs post-surgery follow-ups
Design
Prospective cohort study
Follow-up
6 months
Authors
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Metabolic gains precede inflammatory resolution post-bariatric surgery; leaves open sequencing of Th1/Th17 responses for prospective trials.
Cohort (n=32)
No
Absolute Event Rate: 1.3% vs 3.4%
p-value: p=<0.001
In patients undergoing bariatric surgery, metabolic improvements precede the resolution of systemic inflammation, suggesting metabolic normalization may be required for inflammatory resolution.
Villarreal-Calderón et al. (2021) conducted a cohort in Obesity (n=32). Bariatric and metabolic surgery vs. Preoperative baseline was evaluated on HOMA-IR at 3 months (p=<0.001). Bariatric and metabolic surgery significantly reduced the HOMA-IR index from 3.4 to 1.3 at 3 months, preceding the significant resolution of systemic inflammatory markers at 6 months.
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