What question did this study set out to answer?

To determine whether caloric restriction can overcome chemoresistance to 5-fluorouracil and promote cancer cell death in hepatocellular carcinoma.

October 8, 2024Scientific ReportsOpen Access

5-Fluorouracil induces apoptosis in nutritional deprived hepatocellular carcinoma through mitochondrial damage

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Authors

ADAnkita DuttaIcahn School of Medicine at Mount Sinai ACAnuja Chakraborty TGTulika Ghosh

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Implication

Experimental study reveals nutritional deprivation enhances 5-fluorouracil cytotoxicity via mitochondrial damage in hepatocellular carcinoma cells, suggesting dietary restriction improves...

Key Points

To determine whether caloric restriction can overcome chemoresistance to 5-fluorouracil and promote cancer cell death in hepatocellular carcinoma.
Treated hepatocellular carcinoma and normal control cells with 5-fluorouracil under nutrient-sufficient and nutrient-deficient culture conditions.
Assessed cell death, autophagy induction, mitochondrial membrane integrity, reactive oxygen species generation, and metabolic shifts toward lipid biosynthesis.
Nutritional deprivation combined with 5-fluorouracil markedly increased cancer cell apoptosis by triggering mitochondrial membrane damage and excessive reactive oxygen species production, with negligible harm to normal cells.
The combination treatment induced autophagy and prompted a metabolic shift from glucose utilization to lipid biosynthesis in hepatocellular carcinoma cells.

Cite This Study

Dutta et al. (2024) studied this question.

synapsesocial.com/papers/6a0366e664b0e44ce79bd3a4 https://doi.org/10.1038/s41598-024-73143-y

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Implication

Experimental study reveals nutritional deprivation enhances 5-fluorouracil cytotoxicity via mitochondrial damage in hepatocellular carcinoma cells, suggesting dietary restriction improves...

5-Fluorouracil induces apoptosis in nutritional deprived hepatocellular carcinoma through mitochondrial damage

Discussion

Member takes

Implication

Key Points

Cite This Study

5-Fluorouracil induces apoptosis in nutritional deprived hepatocellular carcinoma through mitochondrial damage

Discussion

Member takes

Implication

Key Points

Cite This Study

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