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A versatile one-pot synthesis of substituted isoindolinones from 2-furaldehydes, amines, 2-(phenylselanyl)acrylic acids, and isocyanides is described. The tandem process involves the Ugi four-component condensation, intramolecular Diels-Alder cycloaddition, and subsequent deselenization-aromatization promoted by BF(3)-OEt(2). The procedure is general and efficient and the substrates are easily available.
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Huang et al. (2009) studied this question.
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