What question did this study set out to answer?

This research aims to explore how estrogen plus progestin affects the characteristics of breast cancers and mammography outcomes in postmenopausal women.

June 24, 2003JAMA

Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women

View Full Paper

Ask AI

Bookmark

Authors

RCRowan T. ChlebowskiUniversity of Vermont SHSusan L. HendrixGeorgia Southern University RLRobert D. LangerUniversity of California, San Diego

Discussion

Member takes

Implication

Randomized trial finds increased breast cancer cases and abnormal mammograms in postmenopausal women using hormones, indicating potential risks.

Key Points

This research aims to explore how estrogen plus progestin affects the characteristics of breast cancers and mammography outcomes in postmenopausal women.
Randomized trial involving 16,608 postmenopausal women aged 50-79
Participants were given combined estrogen plus progestin or placebo
Breast cancer characteristics and mammography results were monitored over several years.
Estrogen plus progestin increased total breast cancer cases (245 vs 185; HR 1.24, P<.001)
Invasive breast cancers were diagnosed at a larger size (mean 1.7 cm vs 1.5 cm; P=0.04)
9.4% of women in estrogen plus progestin group had abnormal mammograms compared to 5.4% in the placebo group (P<.001).

Cite This Study

Chlebowski et al. (2003) studied this question.

synapsesocial.com/papers/6a0372fc4cd19404ec86cda3 https://doi.org/10.1001/jama.289.24.3243

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial finds increased breast cancer cases and abnormal mammograms in postmenopausal women using hormones, indicating potential risks.

Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider