Population
Poliovirus particles (135S cell-entry intermediate and 80S empty particles)
Design
Preclinical
Authors
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Hypothesis-generating for poliovirus uncoating mechanisms; leaves open conservation and in vivo relevance across picornaviruses.
Cryo-EM reveals that the amino terminus of VP1 in genome-released poliovirus particles can deviate from icosahedral symmetry, suggesting its movement plays a role in viral uncoating.
Lin et al. (2011) studied this question.
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