August 15, 2001Journal of Virology

Sindbis Virus Variant with a Deletion in the 6K Gene Shows Defects in Glycoprotein Processing and Trafficking: Lack of Complementation by a Wild-Type 6K Gene in trans

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Population

Sindbis virus (SV) variant with a 6K gene partially deleted

Comparison

Partial deletion of the 6K gene and coexpression… vs Wild-type (wt) Sindbis virus

Design

Preclinical

Authors

MSMiguel Ángel SanzCentro de Biología Molecular Severo Ochoa LCLuis CarrascoThe Honourable Society of Lincoln's Inn

Discussion

Member takes

Implication

No clinical translation from this animal model; leaves open mechanistic studies of alphavirus assembly.

Structured PICO

Population

Sindbis virus (SV) variant with a 6K gene partially deleted

Intervention

Partial deletion of the 6K gene and coexpression in trans of a wild-type SV 6K gene

Comparator

Wild-type (wt) Sindbis virus

Outcome

Proteolytic processing of virus glycoprotein precursor, transport of glycoproteins to the plasma membrane, plaque phenotype, and virus buddingsurrogate

The 6K gene in Sindbis virus is essential for proper glycoprotein processing, trafficking, and virus budding, and its defects cannot be complemented in trans.

Cite This Study

Sanz et al. (2001) studied this question.

synapsesocial.com/papers/6a038501630747d66657d756 https://doi.org/10.1128/jvi.75.16.7778-7784.2001

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Sindbis Virus Variant with a Deletion in the 6K Gene Shows Defects in Glycoprotein Processing and Trafficking: Lack of Complementation by a Wild-Type 6K Gene in trans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sindbis Virus Variant with a Deletion in the 6K Gene Shows Defects in Glycoprotein Processing and Trafficking: Lack of Complementation by a Wild-Type 6K Gene in trans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider