May 12, 2026European Heart Journal
Contributions of 31P-magnetic resonance spectroscopy to the understanding of dilated heart muscle disease
Key result
Dilated cardiomyopathy is linked to ~24% lower myocardial CP/ATP ratios vs healthy controls.
- P<0.05
- n=37
Why the study?
Does 31P-magnetic resonance spectroscopy detect impaired cardiac high-energy phosphate metabolism in patients with heart failure due to dilated cardiomyopathy compared to volunteers?
Population
37 participants, comprising 23 patients with heart failure due to dilated cardiomyopathy and 14 volunteers.
Comparison
31P-magnetic resonance (MR) spectroscopy at 1.5 T vs Healthy volunteers
Design
Cross-sectional
Authors
Discussion
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Implication
31P-MR spectroscopy can detect abnormal cardiac high-energy phosphate metabolism in patients with DCM, which correlates with clinical and hemodynamic severity.
Study Design
Type
Cross-Sectional (n=37)
Structured PICO
Does 31P-magnetic resonance spectroscopy detect impaired cardiac high-energy phosphate metabolism in patients with heart failure due to dilated cardiomyopathy compared to volunteers?
P
Population
23 patients with heart failure due to dilated cardiomyopathy (mean ejection fraction 34%) and 14 healthy volunteers.
E
Exposure
31P-magnetic resonance (MR) spectroscopy at 1.5 T
C
Comparator
Healthy volunteers
O
Outcome
Creatine phosphate (CP)/ATP ratiosurrogate
Main Result
Absolute Event Rate: 1.54% vs 2.02%
p-value: p=<0.05
31P-MR spectroscopy can detect abnormal cardiac high-energy phosphate metabolism in patients with DCM, which correlates with clinical and hemodynamic severity.
Cite This Study
Neubauer et al. (1995) conducted a cross-sectional in Heart failure due to dilated cardiomyopathy (DCM) (n=37). Dilated cardiomyopathy vs. Healthy volunteers was evaluated on Creatine phosphate (CP)/ATP ratio (p=<0.05). Patients with dilated cardiomyopathy had significantly reduced myocardial creatine phosphate/ATP ratios compared to healthy volunteers (1.54 vs 2.02; P<0.05).