Why the study?
Does the ACE2/Ang(1-7)/Mas axis protect against lung fibroblast migration and lung fibrosis induced by AngII-mediated ROS?
Does the ACE2/Ang(1-7)/Mas axis protect against lung fibroblast migration and lung fibrosis induced by AngII-mediated ROS?
The ACE2/Ang(1-7)/Mas axis protects against lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rock pathway, suggesting a potential antioxidant therapeutic target.
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Should not yet change lung fibrosis management; leaves open whether ACE2/Ang(1-7) axis benefits translate to humans.
Meng et al. (2014) studied this question.
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