Population
Human lung tissues from patients with idiopathic pulmonary fibrosis, rodent lung tissues from mice subjected…
Comparison
Angiotensin II treatment, with or without AGTR1… vs Normal fibroblasts vs. fibrotic fibroblasts…
Design
Preclinical
Authors
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Animal data support AGTR2 as IPF fibroblast target; leaves open human translation and trials.
A receptor switch from AGTR1 to AGTR2 mediates Angiotensin II-induced migration and proliferation in fibrotic lung fibroblasts, highlighting AGTR2 as a potential therapeutic target in idiopathic pulmonary fibrosis.
Königshoff et al. (2007) studied this question.
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