What question did this study set out to answer?

To determine whether moderate weight loss from a low-calorie diet enhances the clinical response to low-dose cyclosporine in obese patients with moderate-to-severe chronic plaque psoriasis.

November 1, 2008American Journal of Clinical NutritionOpen Access

Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial

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To determine whether moderate weight loss from a low-calorie diet enhances the clinical response to low-dose cyclosporine in obese patients with moderate-to-severe chronic plaque psoriasis.
A 24-week randomized, controlled, investigator-blinded clinical trial (NCT00512187) was conducted in 61 obese adults (body mass index > 30 kg/m²) with moderate-to-severe chronic plaque psoriasis.
Participants were assigned to receive low-dose cyclosporine (2.5 mg/kg/day) paired with either a low-calorie diet (n=30) or cyclosporine monotherapy with an unrestricted diet (n=31).
Mean weight reduction at week 24 was significantly higher in the dietary intervention group compared to controls (7.0% ± 3.5% vs 0.2% ± 0.9%, P < 0.001).
The primary endpoint of a PASI 75 response was achieved by 20 of 30 patients (66.7%) in the diet group versus 9 of 31 patients (29.0%) in the control group (P < 0.001).
Premature study withdrawal occurred in 4 of 30 patients (13.3%) receiving the dietary intervention compared to 14 of 31 patients (45.1%) receiving cyclosporine alone (P < 0.001).

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Implication

Randomized investigator-blinded trial demonstrates that diet-induced weight loss enhances low-dose cyclosporine efficacy in obese patients with psoriasis, suggesting lifestyle interventions aid...

Cite This Study

Gisondi et al. (2008) studied this question.

synapsesocial.com/papers/6a03b52f2ca770c848de0975 https://doi.org/10.3945/ajcn.2008.26427

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Implication

Randomized investigator-blinded trial demonstrates that diet-induced weight loss enhances low-dose cyclosporine efficacy in obese patients with psoriasis, suggesting lifestyle interventions aid...

Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial

Key Points

Discussion

Implication

Cite This Study

Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial

Key Points

Discussion

Implication

Cite This Study

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