August 23, 2005CirculationOpen Access

C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes

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Why the study?

Does high-sensitivity C-reactive protein predict incident cardiovascular disease in an American Indian population with a high prevalence of diabetes?

Population

3,277 American Indian adults aged 45 to 74 years who were CVD-free at baseline. 542 participants with CRP…

Design

Cohort

Follow-up

median 6.2 years

Authors

LBLyle G. BestMissouri Breaks Industries Research (United States)YZYing ZhangSouth China Agricultural University ELElisa T. LeeUniversity of Vermont

Discussion

Member takes

Implication

CRP adds no independent CVD prediction beyond albuminuria and fibrinogen in American Indians; leaves open its incremental value in diabetes- and sex-specific models.

Structured PICO

Does high-sensitivity C-reactive protein predict incident cardiovascular disease in an American Indian population with a high prevalence of diabetes?

Population

3,277 American Indian adults aged 45 to 74 years who were CVD-free at baseline. 542 participants with CRP >10 mg/L were excluded from analysis. Of those included, 50.1% had diabetes.

Intervention

High-sensitivity C-reactive protein (CRP) measurement

Outcome

Incident cardiovascular disease (CVD) eventshard clinical

While CRP predicts cardiovascular disease in American Indians, its predictive utility is attenuated by other inflammatory markers and varies significantly by diabetes status and sex.

Cite This Study

Best et al. (2005) studied this question.

synapsesocial.com/papers/6a03bf38d2c35e4200e969a2 https://doi.org/10.1161/circulationaha.104.489260

Topics

Women and heart disease

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Implication

CRP adds no independent CVD prediction beyond albuminuria and fibrinogen in American Indians; leaves open its incremental value in diabetes- and sex-specific models.

C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider