Why the study?
Does mibefradil or diltiazem prevent tachycardia-induced atrial remodeling in dogs?
Population
Dogs subjected to a 7-day period of atrial pacing at 400 bpm
Comparison
Mibefradil or diltiazem daily, beginning 4 days… vs Placebo and non-paced controls
Design
Preclinical, blinded fashion
Follow-up
11 days (4 days pre-treatment and 7 days pacing)
Authors
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May attenuate tachycardia-induced remodeling via T-type blockade in canines; leaves open translation to human AF prevention.
Does mibefradil or diltiazem prevent tachycardia-induced atrial remodeling in dogs?
The selective T-type calcium channel blocker mibefradil, but not the L-type blocker diltiazem, protects against tachycardia-induced atrial remodeling in a canine model.
Samir Fareh (2001) studied this question.
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