October 1, 1995Circulation
Atrial Fibrillation Begets Atrial Fibrillation
Design
Preclinical
Follow-up
1 week
Authors
Discussion
Loading...
Member takes
Implication
Supports reversible AF remodeling in models; leaves open whether early rhythm control prevents progression in patients.
Structured PICO
I
Intervention
Artificial maintenance of AF
O
Outcome
Shortening of AERP, reversion of physiological rate adaptation, and increase in rate, inducibility and stability of AFsurrogate
Artificial maintenance of atrial fibrillation causes reversible electrophysiological remodeling that promotes further atrial fibrillation, establishing the foundational concept that 'AF begets AF'.
Cite This Study
Wijffels et al. (1995) studied this question.