Why the study?
Does cardioversion to sinus rhythm reverse electrical and structural remodeling in a canine model of chronic AF?
Population
8 dogs with chronic atrial fibrillation induced by creating moderate mitral regurgitation and rapidly pacing…
Comparison
Cardioversion to sinus rhythm and observation at… vs Baseline and established chronic AF state
Design
Preclinical
Follow-up
7 to 14 days after cardioversion
Authors
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Persistent structural changes may sustain AF vulnerability despite electrical recovery; hypothesis-generating for targeted antifibrotic strategies.
Does cardioversion to sinus rhythm reverse electrical and structural remodeling in a canine model of chronic AF?
In a canine model of chronic AF, reverse electrical remodeling occurs rapidly after cardioversion, but structural abnormalities and vulnerability to AF persist, suggesting structural changes drive long-term AF vulnerability.
Everett et al. (2000) studied this question.
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