June 1, 1995Hypertension
Influence of Blood Pressure on Left Atrial Size
Why the study?
Do contemporary and long-term measures of blood pressure associate with echocardiographically determined left atrial size in a population-based cohort?
Population
4,001 participants (1,849 male and 2,152 female) of the Framingham Heart Study and Framingham Offspring Study
Comparison
Increased levels of blood pressure vs Lower levels of blood pressure
Design
Cohort
Follow-up
8-year average (for blood pressure measurement)
Authors
Discussion
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Implication
Elevated long-term systolic BP may increase LA enlargement risk; hypothesis-generating for whether BP control prevents atrial remodeling.
Key Points
- To evaluate the association between blood pressure measures and left atrial size in a large cohort.
- Analyzed data from 1849 males and 2152 females from the Framingham studies.
- Performed sex-specific correlation and multivariable linear regression analyses.
- Conducted logistic analyses on average systolic pressure in relation to left atrial enlargement.
- Systolic and pulse pressures were significant determinants of left atrial size (partial r < or = .10).
- Subjects with 8-year average systolic pressure of 140 mm Hg or higher had double the risk of left atrial enlargement compared to those with pressures of 110 mm Hg or lower.
- Associations were attenuated when including left ventricular mass in the regression models.
Structured PICO
Do contemporary and long-term measures of blood pressure associate with echocardiographically determined left atrial size in a population-based cohort?
P
Population
4,001 participants (1,849 male and 2,152 female) of the Framingham Heart Study and Framingham Offspring Study
I
Intervention
Increased levels of blood pressure (systolic, diastolic, pulse pressure, and mean arterial pressure)
C
Comparator
Lower levels of blood pressure (e.g., 8-year average systolic pressure ≤110 mm Hg)
O
Outcome
Echocardiographically determined left atrial size and left atrial enlargementsurrogate
Increased systolic and pulse pressures are significantly associated with increased left atrial size, though the relationship is modest and attenuated by left ventricular mass.
Cite This Study
Vaziri et al. (1995) studied this question.