March 7, 2006Circulation
Intracoronary Bone Marrow Cell Transfer After Myocardial Infarction
Why the study?
Does a single dose of intracoronary autologous bone marrow cells improve long-term left ventricular ejection fraction in patients after acute myocardial infarction?
Population
60 patients after acute myocardial infarction who underwent percutaneous coronary intervention with stent…
Comparison
Single dose of intracoronary autologous bone… vs Optimal postinfarction therapy alone.
Design
RCT, 1:1
Follow-up
18+/-6 months
Authors
Discussion
Loading...
Member takes
Implication
BMC infusion does not improve long-term LVEF after AMI; challenges durable regenerative benefit and directs trials to repeated dosing or alternative cells.
Structured PICO
Does a single dose of intracoronary autologous bone marrow cells improve long-term left ventricular ejection fraction in patients after acute myocardial infarction?
P
Population
60 patients after acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI) with stent implantation of the infarct-related artery.
I
Intervention
Single dose of intracoronary autologous bone marrow cell (BMC) infusion administered 4.8+/-1.3 days after PCI, added to optimal postinfarction therapy.
C
Comparator
Optimal postinfarction therapy alone.
O
Outcome
Change in mean global left ventricular (LV) ejection fraction measured by cardiac MRI at 6 and 18 months.surrogate
Intracoronary bone marrow cell transfer after AMI accelerates early LVEF recovery but does not provide a sustained long-term benefit on LV systolic function at 18 months.
Cite This Study
Meyer et al. (2006) studied this question.