November 2, 2005European Heart Journal103 citationsOpen Access
View Full PaperMobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction
Structured PICO
P
Population
43 patients with ST-segment elevation myocardial infarction (STEMI)
O
Outcome
Correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood and left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markerssurrogate
Early mobilization of specific stem cell populations in STEMI patients correlates positively with preserved LVEF and negatively with NT-proBNP and necrosis markers, suggesting a potential role in myocardial recovery.
Abstract
AIMS: The aim of the study was to assess the correlation between the number of CD34(+), CD117(+), c-met(+), CXCR4(+) stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (40%. The number of CXCR4(+) cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=-0.37; P=0.029 and r=-0.45, P=0.02) and maximum activity of CK-MB (r=-0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found. CONCLUSION: The mobilization of CD34(+), CD117(+), CXCR4(+), c-met(+) stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.