Why the study?
Does intracoronary versus intravenous delivery, and CD34+ enrichment versus unselected bone marrow cells, improve myocardial homing in patients with a first STEMI?
Population
9 patients with a first ST-segment-elevation myocardial infarction who had undergone stenting of the…
Design
Case_series
Follow-up
50 to 75 minutes after cell transfer
Authors
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May enhance myocardial homing after STEMI with intracoronary CD34-enriched cells; hypothesis-generating, requires randomized trials before practice consideration.
Does intracoronary versus intravenous delivery, and CD34+ enrichment versus unselected bone marrow cells, improve myocardial homing in patients with a first STEMI?
18F-FDG labeling with 3D PET imaging is a feasible method to monitor the biodistribution of bone marrow cells, demonstrating that intracoronary delivery and CD34+ enrichment significantly increase myocardial homing compared to intravenous delivery and unselected cells.
Hofmann et al. (2005) studied this question.
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