Why the study?
Does myocardial infarction mobilize bone marrow-derived cells expressing early cardiac markers into the peripheral blood?
Population
Mice (young and aging) and human bone marrow mononuclear cells
Design
Preclinical
Authors
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Does not alter MI management; leaves open functional contribution of these mobilized cells to human cardiac regeneration.
Does myocardial infarction mobilize bone marrow-derived cells expressing early cardiac markers into the peripheral blood?
The discovery of bone marrow-derived nonhematopoietic cells expressing early cardiac markers that mobilize after myocardial infarction provides a potential mechanism for cardiac regeneration.
Kucia et al. (2004) studied this question.
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