January 26, 2022Heart Failure Reviews38 citationsOpen Access

Left atrial structure and function in heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF): systematic review and meta-analysis

XJXuanyi JinTulane University JNJan F. NautaUniversity Medical Center Groningen CHChung‐Lieh HungHeart Failure & Transplant

Structured PICO

Does left atrial structure and function differ between patients with HFrEF and HFpEF?

Population

Patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF)

Intervention

Heart failure with reduced ejection fraction (HFrEF)

Comparator

Heart failure with preserved ejection fraction (HFpEF)

Outcome

Left atrial structure and function (including LA global function, LAVi, and E/e')surrogate

Left atrial myopathy is not specifically related to HFpEF, as patients with HFrEF demonstrate worse LA global function despite a lower burden of atrial fibrillation.

Abstract

WMD = 16.3% (22.05,8.61); p < 0.001, and higher E/e' WMD = -0.40 (-0.56, -0.24); p < 0.05, while LAVi was comparable. When focusing on acute hospitalized patients, E/e' was comparable between patients with HFrEF and HFpEF. Despite the higher burden of AF in HFpEF, patients with HFrEF had worse LA global function. Left atrial myopathy is not specifically related to HFpEF.

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