Why the study?
Do renin-angiotensin system inhibitors prevent atrial fibrillation development in patients with congestive heart failure?
Do renin-angiotensin system inhibitors prevent atrial fibrillation development in patients with congestive heart failure?
RAS inhibitors may prevent the development of atrial fibrillation in patients with congestive heart failure by mitigating atrial remodeling.
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Supports RAS inhibitor prioritization in HF to curb new AF; reinforces remodeling mitigation as key mechanism.
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia encountered clinically in patients with congestive heart failure (CHF) and has been associated with increased morbidity and possibly mortality. Small retrospective studies have shown a preventive effect on AF development with the use of agents interfering with the renin-angiotensin system (RAS). Method and Results:We carried out a systematic search of the literature in the English language in order to elucidate the potential mechanism underlying this added beneficial effect of RAS inhibitors in CHF. The concepts of ionic, electrical and structural remodelling of the atrium induced by AF are discussed. Conclusion: Inhibition of RAS could prevent AF development in patients with CHF.
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Palardy et al. (2005) studied this question.
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