Why the study?
Does linezolid dose and trough concentration correlate with mitochondrial toxicity-related adverse events in patients with chronic extensively drug-resistant tuberculosis?
Population
38 participants with chronic extensively drug-resistant tuberculosis
Comparison
Linezolid 600 mg vs Linezolid 300 mg
Design
RCT
Authors
Loading...
Linezolid 600 mg raises mitochondrial toxicity risk versus 300 mg; supports trough monitoring below 2 μg/ml to guide dosing in XDR-TB.
Does linezolid dose and trough concentration correlate with mitochondrial toxicity-related adverse events in patients with chronic extensively drug-resistant tuberculosis?
Therapeutic drug monitoring of linezolid trough concentrations may help prevent mitochondrial toxicity in patients treated for extensively drug-resistant tuberculosis.
Song et al. (2015) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: