What question did this study set out to answer?

The aim of the research is to address sepsis-associated inflammation and infection through targeted therapy.

May 13, 2026Journal of Materials Chemistry B0 citationsOpen Access

Dual-Targeting Sepsis-Associated Inflammation and Infection Using Linoleic Acid-Based Lipid-Polymer Hybrid Nanoparticles

ATAbdelrahman TageldinUniversity of KwaZulu-Natal COCalvin A. OmoloAfrica International University VNVincent O. NyandoroKabarak University

Key Points

The aim of the research is to address sepsis-associated inflammation and infection through targeted therapy.
Utilized linoleic acid-based lipid-polymer hybrid nanoparticles for drug delivery
Assessed effects on inflammation and bacterial infection
Evaluated mortality outcomes in a sepsis model
Showed significant reduction in inflammation markers
Decreased bacterial load
Reduced mortality rate compared to control groups

Abstract

Bacterial sepsis is a critical and life-threatening condition resulting from a dysregulated host immune response to infection and remains one of the foremost causes of mortality worldwide. In this study,...

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Cite This Study

Tageldin et al. (Thu,) studied this question.

synapsesocial.com/papers/6a03cb781c527af8f1ecf174 https://doi.org/https://doi.org/10.1039/d6tb00207b

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