Dual-Targeting Sepsis-Associated Inflammation and Infection Using Linoleic Acid-Based Lipid-Polymer Hybrid Nanoparticles

Abdelrahman Tageldin; Calvin A. Omolo; Vincent O. Nyandoro; Eman A. Ismail; Mohammed A. Gafar; Bongani Nkambule; Lucy Kiruri; Irene Mackraj; Thirumala Govender

doi:10.1039/d6tb00207b

January 1, 2026Journal of Materials Chemistry BOpen Access

Dual-Targeting Sepsis-Associated Inflammation and Infection Using Linoleic Acid-Based Lipid-Polymer Hybrid Nanoparticles

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim of the research is to address sepsis-associated inflammation and infection through targeted therapy.
Utilized linoleic acid-based lipid-polymer hybrid nanoparticles for drug delivery
Assessed effects on inflammation and bacterial infection
Evaluated mortality outcomes in a sepsis model
Showed significant reduction in inflammation markers
Decreased bacterial load
Reduced mortality rate compared to control groups

Implication

This research demonstrates reduced inflammation and mortality in sepsis using linoleic acid-based nanoparticles, suggesting a novel treatment approach.

Abstract

Bacterial sepsis is a critical and life-threatening condition resulting from a dysregulated host immune response to infection and remains one of the foremost causes of mortality worldwide. In this study,...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Tageldin et al. (2026) studied this question.

synapsesocial.com/papers/6a03cb781c527af8f1ecf174 https://doi.org/10.1039/d6tb00207b

View Full Paper

Ask AI

Bookmark

Share

Dual-Targeting Sepsis-Associated Inflammation and Infection Using Linoleic Acid-Based Lipid-Polymer Hybrid Nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

Dual-Targeting Sepsis-Associated Inflammation and Infection Using Linoleic Acid-Based Lipid-Polymer Hybrid Nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading