Investigation of 2,3-diaryl-1,4-thiazolidin-4-ones as promising agents for reducing lipid accumulation in liver cell through AMPK activation: synthesis, in vitro , in silico and lipidomic studies

Key Points

• The study aims to identify potent lipid-lowering agents from thiazolidin-4-ones through synthesis and biological evaluation.
• Utilized a sealed-tube, acid-catalyzed three-component synthesis for thiazolidin-4-ones.
• Conducted in vitro and in silico experiments to evaluate lipid-lowering potential.
• Performed lipidomic studies to analyze lipid accumulation effects.
• Achieved efficient synthesis of thiazolidin-4-ones.
• Demonstrated significant reduction in lipid accumulation in liver cells.
• Identified specific derivatives with enhanced biological activity.