Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation.

= 145) with high- or moderate-reward sensitivity across 20-days of ecological momentary assessment. Significant interaction effects were observed such that high-reward individuals experienced more reward-relevant life events and associated SRD. Moderated mediation analysis supported the integrated model at the daily level for depressive symptoms. For hypomanic symptoms, there was not a significant indirect effect nor moderation by reward group. Findings suggest hypersensitivity to reward amplifies the effects of reward-relevant life events on SRD, contributing to the onset of depressive symptoms in individuals at-risk for BSD. Results highlight potential early intervention targets. (PsycInfo Database Record (c) 2026 APA, all rights reserved).