The study demonstrates mapping methods revealing intratumoral heterogeneity, indicating varied oxygenation in tumors.
PURPOSE: . METHODS: maps. RESULTS: maps revealed marked intratumoral heterogeneity: the hypoxic core on average showed no increase in oxygenation due to hyperoxygenation, whereas peripheral and muscle-adjacent regions exhibited increased oxygenation. CONCLUSION: mapping. By combining OxyChip technology, clinical EPR systems, and standard MRI platforms, this approach holds promise for translation into hypoxia-guided radiation therapy planning.
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Ubert et al. (2026) studied this question.
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