Assessing the functional selectivity of an arsenic sensing protein in vitro and in vivo

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This is a In Vitro Study study.

Á. Tóth; Bálint Hajdu; Zeyad H Nafaee; Réka Sára Gyimesi; Béla Gyurcsik; Éva Hunyadi‐Gulyás; J. G. Correia; Juliana Schell; Thanh Huong Dang; Kohsuke Kato; Atsushi Kawaguchi; Lars Hemmingsen; Attila Jancsó

doi:10.1039/d6qi00876c

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Assessing the functional selectivity of an arsenic sensing protein in vitro and in vivo

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Key Points

Evaluate the functional selectivity of arsenic sensing protein using in vitro and in vivo approaches.
Assessment of bacterial ArsR proteins
Measurement of responses to As III and Sb III
Analysis of binding interactions at cysteine coordination sites
Functional selectivity was demonstrated in arsenic sensing protein
Binding of metalloids triggered an allosteric mechanism
Responses varied under in vitro and in vivo conditions

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Implication

Experimental assessment shows functional selectivity and allosteric mechanism of arsenic sensing protein.

Abstract

The homodimeric bacterial ArsR proteins respond to As III and Sb III . Binding of the metalloids at coordination sites formed by three cyteine residues triggers an allosteric mechanism, leading to the release...

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Cite This Study

Tóth et al. (2026) studied this question.

synapsesocial.com/papers/6a03cb9d1c527af8f1ecf62f https://doi.org/10.1039/d6qi00876c

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Assessing the functional selectivity of an arsenic sensing protein in vitro and in vivo

Key Points

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Implication

Abstract

Discussion

Cite This Study

Assessing the functional selectivity of an arsenic sensing protein in vitro and in vivo

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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