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May 13, 2026Journal of Trauma and Acute Care Surgery

Neurosurgical and prehospital timing in severe traumatic brain injury: Insights from the prospective Resuscitation Outcomes Consortium hypertonic saline trial

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Authors

PKPatrick KramerJohns Hopkins UniversityVVVikas N. VattipallyJohns Hopkins UniversityAMArjun K. MentaJohns Hopkins University

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Implication

Retrospective study shows neurosurgical timing affects mortality in traumatic brain injury, suggesting urgency for intervention.

Key Points

  • To evaluate how prehospital time, emergency department duration, and neurosurgical timing influence outcomes in severe traumatic brain injury.
  • Retrospective cohort study using data from the Resuscitation Outcomes Consortium TBI trial
  • Included adult patients with severe traumatic brain injury (GCS ≤8)
  • Applied multivariable logistic and ordinal regression to analyze associations with outcomes
  • No association between prehospital time and inpatient mortality was observed
  • Delays in ICP monitor placement linked to increased mortality and poorer Glasgow Outcome Scale Extended scores
  • In patients needing urgent cranial surgery, each hour's delay in ICP monitoring increased mortality odds by 7%

Cite This Study

Kramer et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbbe1c527af8f1ecf756https://doi.org/10.1097/ta.0000000000005003
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