Corneal deposits secondary to rifapentine therapy: A case report

We report a rare case of rifapentine-associated corneal deposits in a 62-year-old woman with intermediate uveitis on treatment for latent tuberculosis. She has completed a 12-week course of rifapentine with isoniazid, and at routine follow-up 7 months later, bilateral subepithelial corneal opacities were incidentally detected. Anterior segment optical coherence tomography confirmed hyperreflective anterior corneal deposits. No other causative factors were identified. While similar deposits have been reported with rifabutin, this is the first documentation with rifapentine. The deposits were asymptomatic and non-vision-threatening, suggesting a possible class effect among rifamycin and underscoring the need for ophthalmic surveillance in such patients.