Retrospective analysis shows inflammatory biomarkers aid diagnosis of myocarditis versus perimyocardial syndromes in children, indicating potential for targeted triage.
Key Points
Evaluate the diagnostic value of inflammatory biomarkers in differentiating myocarditis from perimyocardial syndromes in children.
Retrospective analysis of pediatric patients aged 1-18 diagnosed with myocarditis or perimyocardial syndromes.
Analyzed clinical characteristics, laboratory data, ECG, and echocardiogram findings.
Calculated Systemic Immune-Inflammation Index using neutrophil, platelet, and lymphocyte counts.
166 eligible subjects enrolled, with 74 myocarditis, 63 myopericarditis, and 21 perimyocarditis cases.
Significantly lower SII observed in myocarditis compared to other groups (p < 0.001).
SII showed AUC of 0.803 for distinguishing perimyocardial syndromes, with optimal cut-off sensitivity and specificity values.