What question did this study set out to answer?

To investigate the association between baseline patient-reported outcomes and early survival in breast cancer patients undergoing pharmacotherapy.

May 13, 2026Medical SciencesOpen Access

Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study

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Authors

HSHenry SutantoAirlangga University MSM. SavitriAirlangga University EHEen HendarsihRumah Sakit Umum Haji Surabaya

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Implication

Prospective cohort study finds that baseline patient-reported outcomes predict survival during first pharmacotherapy in breast cancer, suggesting early risk assessment benefits.

Key Points

To investigate the association between baseline patient-reported outcomes and early survival in breast cancer patients undergoing pharmacotherapy.
Conducted a prospective cohort study at two secondary referral hospitals in Indonesia.
Enrolled women with breast cancer beginning systemic pharmacotherapy and followed them through the first treatment cycle.
Compared baseline demographic, clinical, and patient-reported outcomes between survivors and non-survivors.
Utilized Mann–Whitney U tests for statistical comparisons and ROC curve analyses for evaluating the performance of PRO domains.
Non-survivors had a higher likelihood of metastatic disease (71.4% vs. 25.3%).
Survivors reported significantly higher global health scores (83.3 vs. 41.7; p < 0.001) and better physical, emotional, and social functioning (all p < 0.05).
Higher symptom burden in non-survivors included pain, appetite loss, constipation, systemic side effects, arm symptoms, and financial difficulty (all p < 0.05).
ROC analysis revealed strong discriminative performance for global health status (AUC 0.907; p < 0.001) and emotional and social functioning (AUCs 0.846 and 0.843, respectively).

Cite This Study

Sutanto et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbfc1c527af8f1ecfcab https://doi.org/10.3390/medsci14020247

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Implication

Prospective cohort study finds that baseline patient-reported outcomes predict survival during first pharmacotherapy in breast cancer, suggesting early risk assessment benefits.

Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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