Biphasic modulation of Aβ(1–40) self-assembly by porphyrins: effects of concentration and structural variation

Adèle Brison; Geneviève Pratviel; Christelle Hureau

doi:10.1039/d6qi00446f

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Biphasic modulation of Aβ(1–40) self-assembly by porphyrins: effects of concentration and structural variation

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Key Points

This research aims to examine how porphyrins affect the self-assembly of Aβ(1–40) peptides, particularly in relation to Alzheimer’s disease.
Explored the effects of porphyrins on Aβ(1–40) peptide self-assembly.
Investigated varying concentrations of porphyrins.
Analyzed structural variations of porphyrins.
Porphyrins modulated the self-assembly process of Aβ(1–40) peptides.
Different concentrations led to varying effects on self-assembly.
Findings provide insights into potential therapeutic strategies for Alzheimer’s disease.

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Implication

Findings show modulation of Aβ(1–40) self-assembly by porphyrins at different concentrations, indicating relevance to Alzheimer’s disease.

Abstract

Aβ peptides self-assemble into senile plaques, a hallmark of Alzheimer’s disease (AD). The search for compounds able to modulate peptide self-assembly still await molecular and structural insights. In the present...

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Cite This Study

Brison et al. (2026) studied this question.

synapsesocial.com/papers/6a03cc1b1c527af8f1ecfebd https://doi.org/10.1039/d6qi00446f

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Biphasic modulation of Aβ(1–40) self-assembly by porphyrins: effects of concentration and structural variation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Biphasic modulation of Aβ(1–40) self-assembly by porphyrins: effects of concentration and structural variation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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