Preclinical study demonstrates that M2 microglia-derived extracellular vesicles enhance white matter repair after cerebral ischemia in mice, suggesting a novel therapeutic strategy for stroke.
Our results demonstrated that M2 microglia could communicate to OPCs through M2-EVs and promote white matter repair via miR-23a-5p possibly by directly targeting Olig3 after ischemic stroke, suggesting M2-EVs is a novel and promising therapeutic strategy for white matter repair in stroke and demyelinating disease.
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Li et al. (2022) studied this question.
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